Aggregatibacter actinomycetemcomitans Leukotoxin
نویسندگان
چکیده
منابع مشابه
Virulence Mechanisms of Leukotoxin from Aggregatibacter actinomycetemcomitans
Aggregatibacter actinomycetemcomitans is a gram-negative bacterium that is present in the oral cavity of a large proportion of the human population (Zambon et al., 1983; Henderson et al., 2010) The bacterium is acquired through transmission from infected individuals and thought to initially colonize oral mucosa as a facultative intracellular pathogen (Fine et al., 2006). When the bacteria trans...
متن کاملGangliosides Block Aggregatibacter Actinomycetemcomitans Leukotoxin (LtxA)-Mediated Hemolysis
Aggregatibacter actinomycetemcomitans is an oral pathogen and etiologic agent of localized aggressive periodontitis. The bacterium is also a cardiovascular pathogen causing infective endocarditis. A. actinomycetemcomitans produces leukotoxin (LtxA), an important virulence factor that targets white blood cells (WBCs) and plays a role in immune evasion during disease. The functional receptor for ...
متن کاملHuman CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin.
Aggregatibacter (Actinobacillus) actinomycetemcomitans is the causative organism of localized aggressive periodontitis, a rapidly progressing degenerative disease of the gingival and periodontal ligaments, and is also implicated in causing subacute infective endocarditis in humans. The bacterium produces a variety of virulence factors, including an exotoxic leukotoxin (LtxA) that is a member of...
متن کاملRegulation of Aggregatibacter (Actinobacillus) actinomycetemcomitans leukotoxin secretion by iron.
The gram-negative oral and systemic pathogen Aggregatibacter (Actinobacillus) actinomycetemcomitans produces a leukotoxin (LtxA) that is a member of the RTX (repeats in toxin) family of secreted bacterial toxins. We have recently shown that LtxA has the ability to lyse erythrocytes, which results in a beta-hemolytic phenotype on Columbia blood agar. To determine if LtxA is regulated by iron, we...
متن کاملThe role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis
Aggregatibacter actinomycetemcomitans is a Gram-negative periodontitis-associated bacterium that expresses a toxin that selectively affects leukocytes. Leukotoxin is encoded by an operon belonging to the core genome of this bacterial species. Variations in the expression of the leukotoxin have been reported, and a specific clonal type (JP2) of this bacterium with enhanced leukotoxin expression ...
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ژورنال
عنوان ژورنال: Journal of Dental Research
سال: 2010
ISSN: 0022-0345,1544-0591
DOI: 10.1177/0022034510363682